Useful information about von Willebrand disease


Although generally presented as an independent disease, von Willebrand disease actually belongs to a family of blood disease caused by an abnormality of von Willebrand factor. Von Willebrand disease is the most common hereditary transmitted blood disease. It is a blood disorder characterized by the tendency to bruise easy, frequent nosebleeds and prolonged menstrual bleeding due to quantitative or qualitative abnormalities, depending on the type of von Willebrand factor. Von Willebrand factor is a protein that functions as a “carrier” for coagulation factor VIII.

Von Willebrand disease is transmitted autosomal; gene on chromosome 12 is affected. Depending on the type of von Willebrand disease, may be recessive or dominant transmission. The disease is found at a frequency of one case per 8 00 – 1000 people. It meets with equal frequency in both men and women, unlike hemophilia A or hemophilia B which are occurring more frequently in males. Global prevalence is estimated around 1%. No differences based on race.

Signs and symptoms

The clinical picture can be extremely varied, even within a family. The most frequently describe these events:

Increased tendency to bruise easily

Recurrent epistaxis (nosebleeds repeated)

Prolonged menstrual bleeding (lasting more than 7 days)

Postoperative bleeding or after dental extractions

Bleeding gums (especially in infants and erupting teeth)

Bleeding at birth and immediately after birth

Prolonged bleeding wounds

To see that von Willebrand disease is frequently associated with the following diseases:

Willms Renal Tumor

Congenital heart disease

Systemic lupus erythematosus (SLE)


Epilepsy treated with valproic acid


Von Willebrand disease is divided into three categories: partial quantitative deficiency type I, qualitative deficiency type II and total deficiency type III. Type III is divided into four types: IIA, IIB, IIN, IIM depending on the characteristics of dysfunctional von Willebrand factor. These categories correspond to distinct molecular mechanisms, with correspondent and clinical regimens.

For affected individuals von Willebrand disease is a mild bleeding disorder well controlled. However, there is variability in members of the same family events. In people with type II or III bleeding may be severe and potentially life-threatening. People with type III von Willebrand factor which decreased develop arthropathy. Morbidity and mortality in this disease varies. Most children with von Willebrand disease are asymptomatic. Some shows mucosal bleeding: epistaxis and bruising. Menorrhagia is common in women with von Willebrand disease. Occurs in over 50% of women with von Willebrand disease and may be the only clinical manifestation of the disease. Type III rarely can result in severe bleeding similar to hemophilia: hemarthrosis, intramuscular hemorrhage.

Treatment and Prevention

In minor bleeding and easy epistaxis, no therapeutic intervention is need. In serious bleeding, should be given a number of medications that increase the level and activity of von Willebrand factor.

The goal of treatment is to correct the platelet adhesion defect by increasing levels of von Willebrand factor efficient and correct the coagulation defect by increasing levels of factor VIII needed for a proper hemostasis. In patients with severe bleeding, appropriate and prompt treatment is important to avoid potential complications.

The easiest preventive method for the patient is easy restriction in sports activities, especially in patients with type 3 von Willebrand diseases and to prevent the use drugs with antiplatelet effect of NSAIDs type (Aspirin, Ibuprofen, Naproxen), antihistamines, antibiotics of cephalosporin type, tricyclic antidepressants. A more complete list of medications with antiplatelet effects will be provided to patients by their hematologist.

Calivita natural products to treat Willebrand disease

– In all physiological processes in the body, vitamins and minerals act synergistically. Administration of a single tablet of Full Spectrum provides beneficial substances that the body needs to function optimally.

– Antioxidants and Gingko biloba extract from Protect 4Life and Gingko xc supplement composition have a beneficial effect on blood, both peripheral and central, thus providing better function of the entire body.

– Hesperidine, the active ingredient in the supplement Vein Protex, together with other active ingredients from plant extracts, maintains healthy blood vessels, restore and protect the superficial veins, and take care of the venous system in general.

– Vitamin B Complex found in Stress Management B Complex form has multiple effects on the health of the human body: reduces stress and provides a smooth operation for the nervous system, has an essential role in the synthesis of protein and minerals, improve venous circulation, contributes to adrenal health, etc.


Source by Stefania Constantin

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